In Panosophy, an existential threat is anything that an individual feels endangers their personal sense of identity. Panosophy, as the elusive Theory of Everything, can feel like an existential threat to many because it is transcultural and transdisciplinary, realized through an awakening death-and-rebirth process.

Scientifically, the Unified Relationships Theory can feel threatening because Imre Lakatos said that scientific projects contain a ‘hard core’ that cannot be questioned. Anyone doing so would be ostracized by the scientific community.